Emergency Preparedness

Kern Medical Bioterrorism Response Guide Section 2-C-1 – Smallpox

SMALLPOX VACCINATION INSTRUCTIONS The current vaccine is no longer licensed because of required changes in the diluent preparation for vaccine reconstitution. The changes in diluent do not effect the ability of the vaccine to produce immunity to smallpox. However because the vaccine is no longer licensed it must be labeled as an Investigational New Drug (IND). Supplies ? Vaccination Informed Consent ? Vaccination Consent ? Gloves ? Alcohol wipes ? Alcohol foam or gel (handwashing) ? Vacciniavaccine ? Bifurcated needle (sterile) ? Gauze pads ? Tape (non-allergic) ? Waste receptacle lined with a red bag and syringe disposal container Administrative Requirements ? Distribute smallpox vaccination information and smallpox vaccination consent. ? Collect signed consent and answer questions about vaccineadministration. ? Document date vaccination given, lot number, expiration date, and person administering vaccine on the consentform. Reconstitution of Vaccine with Commercially Packaged Diluent Diluent is required for the reconstitution of smallpox vaccine prior to administration. The diluent to be utilized in this protocol is similar in formulation to the licensed diluent except that it lacks the 0.005% brilliant green. This change in formulation does not effect the ability of the vaccine to produce immunity to smallpox. Directions for Reconstitution Reconstitution of a single vial of smallpox vaccine with 0.25 mL of diluent would yield approximately 100 doses. ? Remove the vaccine vial from refrigerated storage and allow the vial to come to room temperature. ? Lift up the tab of the aluminum seal on the vaccine vial. DO NOT BREAK OFF OR TEAR THE DOWN TAB. ? Wipe the vial stopper with an alcohol pad AND ALLOW TODRY. ? Place the vaccine vial upright on a hard, flat surface. ? Wear disposable gloves when reconstituting the vaccine.

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